ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CHRNA7
Approved Name	cholinergic receptor, nicotinic, alpha 7
Previous Name	cholinergic receptor, nicotinic, alpha polypeptide 7
Location	15q13.3
Position	chr15:32322691-32464722, +
External Links	HGNC: 1960 Entrez Gene: 1139 Ensembl: ENSG00000175344 UCSC: uc001zft.2
No. of Studies	2 (significant: 0; non-significant: 1; trend: 1)
Source	Literature-origin; Mapped by CNV; Mapped by significant region

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Kent L, 2001(a)	The extended Transmission Disequilibrium Test analyses demonstrated no evidence that variation at the microsatellite markers D15S1360, D15S1043, and D15S165 influences susceptibility to ADHD.	Non-significant
Stergiakouli E., 2012	was affected by six large duplications in case subjects (none in comparison subjects), and SNPs in the gene had a gene-wide p value of 0.0002 for association in the GWAS.	Trend

Gene related SNPs (count: 0)

Gene related CNVs (count: 5)

ID	Location	Size	Band	Type
CNV_Williams[2010]_13	chr15:29734334-30300525 (NCBI Build 36.1 (hg18))	566191	15q13.3	Gain
CNV_Williams[2010]_52	chr15:29807358-30319628 (NCBI Build 36.1 (hg18))	512271	15q13.3	Gain
CNV_Williams[2010]_22	chr15:29734334-30302218 (NCBI Build 36.1 (hg18))	593564	15q13.3	Gain
CNV_Jarick[2012]_30	chr15:28797383-30302218 (NCBI36 / hg18)	1504836	15q13.2-15q13.3	dup
CNV_Williams[2010]_2	chr15:29734334-30302218 (NCBI Build 36.1 (hg18))	882305	15q13.3	Gain

Gene related other variant (count: 3)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
CHRNA7_upstream_D15S1360	microsatellite	lies less than 120 kb upstream from the first exon of CHRNA7	1 (0/1/0)
CHRNA7_upstream_D15S1043	microsatellite	lies 0.5 cM centromeric to D15S165, and maps proximally to the duplicated region.	1 (0/1/0)
CHRNA7_upstream_D15S165	microsatellite	lies approximately 2 cM centromeric to D15S1360, and between the full length and duplicated genes.	1 (0/1/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
15q11.2-13.3	chr15:20700000-33600000	1 (1/0/0)
15q13.3	chr15:31200000-33600000	1 (1/0/0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007613	memory	Biological Process	NAS[10681545]	18
GO:0008284	positive regulation of cell proliferation	Biological Process	IMP[17498763]	69
GO:0015464	acetylcholine receptor activity	Molecular Function	IDA[8906617]	5
GO:0015643	toxin binding	Molecular Function	IDA[12508119]	2
GO:0016021	integral to membrane	Cellular Component	NAS[8145738]	845
GO:0017081	chloride channel regulator activity	Molecular Function	IDA[8145738]	2
GO:0030054	cell junction	Cellular Component		77
GO:0032720	negative regulation of tumor necrosis factor production	Biological Process	IDA[12508119]; IMP[12508119]	6
GO:0035094	response to nicotine	Biological Process	IDA[8145738]	6
GO:0042166	acetylcholine binding	Molecular Function	IDA[8145738]	5
GO:0042221	response to chemical stimulus	Biological Process	IDA[18387948]	2
GO:0042803	protein homodimerization activity	Molecular Function	IDA[8145738]	113
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0045766	positive regulation of angiogenesis	Biological Process	IMP[16280133]	12
GO:0050890	cognition	Biological Process	IMP[16754836]; NAS[10681545]	6
GO:0000187	activation of MAPK activity	Biological Process	IDA[10771023]	21
GO:0001666	response to hypoxia	Biological Process	IDA[12189247]	34
GO:0001540	beta-amyloid binding	Molecular Function	IPI[10681545]	6
GO:0005886	plasma membrane	Cellular Component	IDA[12508119]	772
GO:0004889	acetylcholine-activated cation-selective channel activity	Molecular Function	IDA[12508119]	5
GO:0006811	ion transport	Biological Process	NAS[8906617]	25
GO:0005892	acetylcholine-gated channel complex	Cellular Component	IDA[8906617]	5
GO:0006874	cellular calcium ion homeostasis	Biological Process	IMP[16280133]	16
GO:0006816	calcium ion transport	Biological Process	IDA[8145738]; IMP[10771023]	32
GO:0007268	synaptic transmission	Biological Process		96
GO:0007165	signal transduction	Biological Process	IDA[8906617]	171

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with CHRNA7 (count: 14)

Gene Symbol	Pathway Count	Pathway List
CHRNA4	15	acetylcholine receptor activity; integral to membrane; cell junction; response to nicotine; acetylcholine binding; postsynaptic membrane; cognition; response to hypoxia; plasma membrane; acetylcholine-activated cation-selective channel activity; ion transport; acetylcholine-gated channel complex; calcium ion transport; synaptic transmission; signal transduction;
CHRNA3	11	acetylcholine receptor activity; integral to membrane; cell junction; acetylcholine binding; postsynaptic membrane; plasma membrane; acetylcholine-activated cation-selective channel activity; ion transport; acetylcholine-gated channel complex; synaptic transmission; signal transduction;
CHRNB4	10	acetylcholine receptor activity; integral to membrane; cell junction; postsynaptic membrane; plasma membrane; acetylcholine-activated cation-selective channel activity; ion transport; acetylcholine-gated channel complex; synaptic transmission; signal transduction;
CHRNA5	8	acetylcholine receptor activity; cell junction; postsynaptic membrane; plasma membrane; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; synaptic transmission; signal transduction;
ACHE	7	cell junction; acetylcholine binding; protein homodimerization activity; postsynaptic membrane; beta-amyloid binding; plasma membrane; synaptic transmission;
PRKCB	6	positive regulation of angiogenesis; plasma membrane; cellular calcium ion homeostasis; calcium ion transport; synaptic transmission; signal transduction;
GRIN2A	5	memory; cell junction; postsynaptic membrane; plasma membrane; synaptic transmission;
GRIN2B	5	memory; cell junction; postsynaptic membrane; plasma membrane; synaptic transmission;
CHRM1	5	positive regulation of cell proliferation; cell junction; postsynaptic membrane; plasma membrane; signal transduction;
GABRG3	5	integral to membrane; cell junction; postsynaptic membrane; plasma membrane; synaptic transmission;
HTR3A	5	integral to membrane; cell junction; postsynaptic membrane; plasma membrane; synaptic transmission;
CHRM3	5	cell junction; acetylcholine binding; postsynaptic membrane; plasma membrane; signal transduction;
GABRA5	5	cell junction; postsynaptic membrane; plasma membrane; synaptic transmission; signal transduction;
GABRB3	5	cell junction; postsynaptic membrane; plasma membrane; synaptic transmission; signal transduction;

Genes shared at least 2 KEGG pathways with CHRNA7 (count: 30)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr15:32322691..32464722 View in gBrowse