ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CSNK1E
Symbol Alias	HCKIE
Approved Name	casein kinase 1, epsilon
Location	22q13.1
Position	chr22:38686697-38794527, -
External Links	HGNC: 2453 Entrez Gene: 1454 Ensembl: ENSG00000213923 UCSC: uc003avk.2
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Mick E, 2010	Gene-based set test P-value=0.0038. Significant gene-based set tests of association with selected candidates, but contains no significant or Trend associated SNPs.	Significant
Brookes K, 2006	UNPHASED TDT P-value=0.122, global P-value=0.87, WHAP TDT P_sum P-value=0.491, no SNP with nominal P-value<0.05 located in this gene	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process		5
GO:0034613	cellular protein localization	Biological Process		9
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	Biological Process		9
GO:0006468	protein phosphorylation	Biological Process		53
GO:0007165	signal transduction	Biological Process	TAS[7797465]	171
GO:0030178	negative regulation of Wnt receptor signaling pathway	Biological Process		8
GO:0030529	ribonucleoprotein complex	Cellular Component		23
GO:0005524	ATP binding	Molecular Function		228
GO:0005634	nucleus	Cellular Component		770
GO:0005829	cytosol	Cellular Component		447
GO:0006281	DNA repair	Biological Process	TAS[7797465]	62
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0004672	protein kinase activity	Molecular Function		27
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS[7797465]	61
GO:0005515	protein binding	Molecular Function		910
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04340	Hedgehog signaling pathway	8	The Hedgehog (Hh) family of secreted signaling proteins play...... The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes. More...
hsa04710	Circadian rhythm - mammal	6
hsa04310	Wnt signaling pathway	22	Wnt proteins are secreted morphogens that are required for b...... Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. More...

Genes shared at least 5 GO terms with CSNK1E (count: 46)

Gene Symbol	Pathway Count	Pathway List
PLK1	10	positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein phosphorylation; ATP binding; nucleus; cytosol; mitotic cell cycle; protein kinase activity; protein serine/threonine kinase activity; protein binding; G2/M transition of mitotic cell cycle;
LATS2	7	cellular protein localization; protein phosphorylation; ATP binding; nucleus; cytosol; protein serine/threonine kinase activity; protein binding;
GSK3B	7	protein phosphorylation; ribonucleoprotein complex; ATP binding; nucleus; cytosol; protein serine/threonine kinase activity; protein binding;
PRKAA1	7	protein phosphorylation; signal transduction; ATP binding; nucleus; cytosol; protein kinase activity; protein binding;
PRKCB	7	protein phosphorylation; signal transduction; ATP binding; nucleus; cytosol; protein serine/threonine kinase activity; protein binding;
CHEK1	7	ATP binding; nucleus; cytosol; DNA repair; protein serine/threonine kinase activity; protein binding; G2/M transition of mitotic cell cycle;
SMG1	7	ATP binding; nucleus; cytosol; DNA repair; protein kinase activity; protein serine/threonine kinase activity; protein binding;
ILK	6	positive regulation of canonical Wnt receptor signaling pathway; protein phosphorylation; ATP binding; cytosol; protein serine/threonine kinase activity; protein binding;
LATS1	6	protein phosphorylation; ATP binding; cytosol; protein serine/threonine kinase activity; protein binding; G2/M transition of mitotic cell cycle;
NEK6	6	protein phosphorylation; signal transduction; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
PAK1	6	protein phosphorylation; ATP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; protein binding;
ROCK2	6	protein phosphorylation; ATP binding; nucleus; cytosol; protein serine/threonine kinase activity; protein binding;
TGFBR1	6	protein phosphorylation; signal transduction; ATP binding; protein kinase activity; protein serine/threonine kinase activity; protein binding;
MAPK1	6	signal transduction; ATP binding; nucleus; cytosol; protein serine/threonine kinase activity; protein binding;
PRKD1	6	signal transduction; ATP binding; nucleus; cytosol; protein serine/threonine kinase activity; protein binding;
RIPK3	6	signal transduction; ATP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; protein binding;
SMC3	6	signal transduction; ATP binding; nucleus; DNA repair; mitotic cell cycle; protein binding;
CCND1	6	negative regulation of Wnt receptor signaling pathway; nucleus; cytosol; mitotic cell cycle; protein kinase activity; protein binding;
CEP164	6	nucleus; cytosol; DNA repair; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
AURKC	5	protein phosphorylation; ATP binding; nucleus; protein kinase activity; protein serine/threonine kinase activity;
ERBB2	5	protein phosphorylation; signal transduction; ATP binding; nucleus; protein binding;
FYB	5	protein phosphorylation; signal transduction; nucleus; cytosol; protein binding;
MAP3K11	5	protein phosphorylation; ATP binding; protein kinase activity; protein serine/threonine kinase activity; protein binding;
MAPK3	5	protein phosphorylation; ATP binding; nucleus; cytosol; protein binding;
MARK2	5	protein phosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
PRKG1	5	protein phosphorylation; signal transduction; ATP binding; cytosol; protein binding;
RPS6KA4	5	protein phosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
SIK2	5	protein phosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
STK36	5	protein phosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
SYK	5	protein phosphorylation; ATP binding; cytosol; protein kinase activity; protein binding;
ADRBK1	5	signal transduction; ATP binding; cytosol; protein kinase activity; protein binding;
ATM	5	signal transduction; ATP binding; DNA repair; protein serine/threonine kinase activity; protein binding;
MAP2K3	5	signal transduction; ATP binding; cytosol; protein serine/threonine kinase activity; protein binding;
MAPK7	5	signal transduction; ATP binding; nucleus; cytosol; protein binding;
HSPA8	5	ribonucleoprotein complex; ATP binding; nucleus; cytosol; protein binding;
IGHMBP2	5	ribonucleoprotein complex; ATP binding; nucleus; DNA repair; protein binding;
KIF23	5	ATP binding; nucleus; cytosol; mitotic cell cycle; protein binding;
KIF2C	5	ATP binding; nucleus; cytosol; mitotic cell cycle; protein binding;
PIK3CG	5	ATP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; protein binding;
PSMC3	5	ATP binding; nucleus; cytosol; mitotic cell cycle; protein binding;
SMC1A	5	ATP binding; nucleus; DNA repair; mitotic cell cycle; protein binding;
CEP57	5	nucleus; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
NUMA1	5	nucleus; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
PAFAH1B1	5	nucleus; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
PTTG1	5	nucleus; cytosol; DNA repair; mitotic cell cycle; protein binding;
TUBGCP2	5	nucleus; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;

Genes shared at least 2 KEGG pathways with CSNK1E (count: 4)

Gene Symbol	Pathway Count	Pathway List
GSK3B	2	Hedgehog signaling pathway; Wnt signaling pathway;
WNT10A	2	Hedgehog signaling pathway; Wnt signaling pathway;
WNT11	2	Hedgehog signaling pathway; Wnt signaling pathway;
WNT6	2	Hedgehog signaling pathway; Wnt signaling pathway;

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Region: chr22:38686697..38794527 View in gBrowse