Gene Report
Basic Info
Approved Symbol |
GNAZ
|
Approved Name |
guanine nucleotide binding protein (G protein), alpha z polypeptide |
Location |
22q11.1-q11.2 |
Position |
chr22:23412540-23467224, + |
External Links |
HGNC: 4395
Entrez Gene: 2781
Ensembl: ENSG00000128266
UCSC: uc002zwu.1
|
No. of Studies |
1 (significant: 0; non-significant: 1; trend: 0) |
Source |
Literature-origin |
Gene related studies (count: 1)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 4)
Gene related regions (count: 0)
Gene related GO terms (count: 17)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04730 |
Long-term depression |
27 |
Cerebellar long-term depression (LTD), thought to be a molec......
Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization.
More...
|
Genes shared at least 5 GO terms with GNAZ (count: 7)
Genes shared at least 2 KEGG pathways with GNAZ (count: 0)
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