ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NPAS3
Symbol Alias	MOP6, PASD6, bHLHe12
Approved Name	neuronal PAS domain protein 3
Location	14q12-q13
Position	chr14:33408449-34273382, +
External Links	HGNC: 19311 Entrez Gene: 64067 Ensembl: ENSG00000151322 UCSC: uc001wrs.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Weber H, 2011	1 SNP showed significant association with ADHD before Bonferroni correction	Significant

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs17455703	Chr14:33489372(Fwd)	intron_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	No. of Genes in ADHDgene
GO:0042711	maternal behavior	Biological Process	3
GO:0035176	social behavior	Biological Process	9
GO:0046983	protein dimerization activity	Molecular Function	26
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	80
GO:0003677	DNA binding	Molecular Function	220
GO:0005634	nucleus	Cellular Component	770
GO:0004871	signal transducer activity	Molecular Function	49
GO:0005737	cytoplasm	Cellular Component	690
GO:0005730	nucleolus	Cellular Component	243
GO:0007626	locomotory behavior	Biological Process	24
GO:0006351	transcription, DNA-dependent	Biological Process	247

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NPAS3 (count: 15)

Gene Symbol	Pathway Count	Pathway List
TBX1	6	social behavior; protein dimerization activity; positive regulation of transcription, DNA-dependent; DNA binding; nucleus; transcription, DNA-dependent;
MAPK1	6	positive regulation of transcription, DNA-dependent; DNA binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
EBF1	5	protein dimerization activity; positive regulation of transcription, DNA-dependent; DNA binding; nucleus; transcription, DNA-dependent;
ID2	5	protein dimerization activity; positive regulation of transcription, DNA-dependent; nucleus; cytoplasm; nucleolus;
POU2F3	5	protein dimerization activity; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
TFAP2A	5	protein dimerization activity; positive regulation of transcription, DNA-dependent; nucleus; cytoplasm; nucleolus;
HINFP	5	positive regulation of transcription, DNA-dependent; DNA binding; nucleus; nucleolus; transcription, DNA-dependent;
ATXN1	5	DNA binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
BCLAF1	5	DNA binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
HOXB1	5	DNA binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
TCF25	5	DNA binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
XRCC5	5	DNA binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
ZNF263	5	DNA binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
ZNF367	5	DNA binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;
ZNF77	5	DNA binding; nucleus; cytoplasm; nucleolus; transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with NPAS3 (count: 0)

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Region: chr14:33408449..34273382 View in gBrowse