ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TDO2
Symbol Alias	TDO, TPH2
Approved Name	tryptophan 2,3-dioxygenase
Location	4q31-q32
Position	chr4:156775890-156841558, +
External Links	HGNC: 11708 Entrez Gene: 6999 Ensembl: ENSG00000151790 UCSC: uc003ipf.1
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Comings DE, 1996	One of four investigated polymorphisms in this gene was significantly associated with ADHD.	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 4)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
TDO2_exon7_A(Asn)->C(His)	point mutation	exon 7	1 (0/1/0)
TDO2_intron6_G->T	point mutation	intron 6	1 (1/0/0)
TDO2_intron6_G->A	point mutation	intron 6	1 (0/1/0)
TDO2_intron5_(CCCCT)n	microsatellite	3' end of intron 5	1 (0/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

ID	Name	Type	No. of Genes in ADHDgene
GO:0019441	tryptophan catabolic process to kynurenine	Biological Process	1
GO:0019442	tryptophan catabolic process to acetyl-CoA	Biological Process	1
GO:0006569	tryptophan catabolic process	Biological Process	2
GO:0016597	amino acid binding	Molecular Function	8
GO:0005506	iron ion binding	Molecular Function	20
GO:0005829	cytosol	Cellular Component	447
GO:0004833	tryptophan 2,3-dioxygenase activity	Molecular Function	1
GO:0020037	heme binding	Molecular Function	23
GO:0019825	oxygen binding	Molecular Function	5
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0034641	cellular nitrogen compound metabolic process	Biological Process	30

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00380	Tryptophan metabolism	12
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with TDO2 (count: 4)

Gene Symbol	Pathway Count	Pathway List
HAAO	5	tryptophan catabolic process; cytosol; oxygen binding; small molecule metabolic process; cellular nitrogen compound metabolic process;
TH	5	amino acid binding; cytosol; oxygen binding; small molecule metabolic process; cellular nitrogen compound metabolic process;
TPH1	5	amino acid binding; iron ion binding; cytosol; small molecule metabolic process; cellular nitrogen compound metabolic process;
TPH2	5	amino acid binding; iron ion binding; cytosol; small molecule metabolic process; cellular nitrogen compound metabolic process;

Genes shared at least 2 KEGG pathways with TDO2 (count: 11)

Gene Symbol	Pathway Count	Pathway List
AANAT	2	Tryptophan metabolism; Metabolic pathways;
ACAT1	2	Tryptophan metabolism; Metabolic pathways;
ALDH3A2	2	Tryptophan metabolism; Metabolic pathways;
ASMT	2	Tryptophan metabolism; Metabolic pathways;
DDC	2	Tryptophan metabolism; Metabolic pathways;
ECHS1	2	Tryptophan metabolism; Metabolic pathways;
HAAO	2	Tryptophan metabolism; Metabolic pathways;
MAOA	2	Tryptophan metabolism; Metabolic pathways;
MAOB	2	Tryptophan metabolism; Metabolic pathways;
TPH1	2	Tryptophan metabolism; Metabolic pathways;
TPH2	2	Tryptophan metabolism; Metabolic pathways;

View in gBrowse

Region: chr4:156775890..156841558 View in gBrowse