ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Region Report

Basic Info

Region Name	7p15
Chromosome Position	chr7:20900000-28800000
#studies (significant/non-significant/trend)	2(1/1/0)

Region related studies (count: 2)

Reference	Markers	Statistical Values	Author Comments	Result of Statistical Analysis
Lesch KP, 2011	a ~3Mb duplication (CNVs) located on chromosome 7p15.2-15.3	empirical FBAT: P=0.023 for NPY plasma concentration analysi...... empirical FBAT: P=0.023 for NPY plasma concentration analysis, P=0.138 for biased transmission analysis, P=0.117 for binge eating, P=0.192 for BMI More...	Nominally significant association with increased NPY plasma ...... Nominally significant association with increased NPY plasma concentrations was found. There was a trend towards a preferable transmission of the 7p15 duplication to affected family members and binge eating. However, these results did not reach an overall significance level if corrected by Bonferroni's approach. The empirical FBAT for BMI indicated no association with this trait. More...	Significant
Fisher SE, 2002	D7S516	MLS single-point LOD=1.24 under narrow scheme, MLS single-po...... MLS single-point LOD=1.24 under narrow scheme, MLS single-point LOD=1.23 under broad scheme More...	no linkage no linkage	Non-significant

Region related genes (count: 70)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
CREB5	cAMP responsive element binding protein 5	7p15	1(0/0/1)

Genes from other sources (count: 69)

Approved Symbol	Approved Name	Location
CLK2P	CDC-like kinase 2, pseudogene	7p15.3
MIR196B	microRNA 196b	7p15.2
C7orf71	chromosome 7 open reading frame 71	7p15.2
CCDC126	coiled-coil domain containing 126	7p15.3
C7orf30	chromosome 7 open reading frame 30	7p15.3
KLHL7	kelch-like 7 (Drosophila)	7p15.3
STK31	serine/threonine kinase 31	7
EEF1A1P6	eukaryotic translation elongation factor 1 alpha 1 pseudogene 6	7p15.3
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	7p15
CYCS	cytochrome c, somatic	7p21.2
RNU1-15P	RNA, U1 small nuclear 15, pseudogene	7p15.3
DFNA5	deafness, autosomal dominant 5	7p15
RPL12P10	ribosomal protein L12 pseudogene 10	7p15.3
TPM3P4	tropomyosin 3 pseudogene 4	7p15.2
MIR148A	microRNA 148a	7p15.2
KIAA0087	KIAA0087	7p15.2
RPS26P32	ribosomal protein S26 pseudogene 32	7p15.3
RPL35P4	ribosomal protein L35 pseudogene 4	7p15.2
GPNMB	glycoprotein (transmembrane) nmb	7p
IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3	7p15.3
RPS2P30	ribosomal protein S2 pseudogene 30	7p15.1
TOMM7	translocase of outer mitochondrial membrane 7 homolog (yeast)	7p15.3
TRA2A	transformer 2 alpha homolog (Drosophila)	7p15.3
RPL7AP41	ribosomal protein L7a pseudogene 41	7p15.2
DNAH11	dynein, axonemal, heavy chain 11	7p21
RPL7AP38	ribosomal protein L7a pseudogene 38	7p15.2
OSBPL3	oxysterol binding protein-like 3	7p15.3
SP4	Sp4 transcription factor	7p15
HOXA4	homeobox A4	7p15.2
HOXA3	homeobox A3	7p15.2
HOXA6	homeobox A6	7p15.2
NFE2L3	nuclear factor (erythroid-derived 2)-like 3	7p15.2
HOXA5	homeobox A5	7p15.2
NUPL2	nucleoporin like 2	7p15
HOXA9	homeobox A9	7p15.2
HOXA7	homeobox A7	7p15.2
RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5	7p15.3
NPY	neuropeptide Y	7p15.3
NPVF	neuropeptide VF precursor	7p21-p15
SNX10	sorting nexin 10	7p15.2
NHP2P2	NHP2 ribonucleoprotein homolog (yeast) pseudogene 2	7p15.2
HOTTIP	HOXA distal transcript antisense RNA (non-protein coding)	7p15.2
HOTAIRM1	HOXA transcript antisense RNA, myeloid-specific 1 (non-protein coding)	7p15.2
HOXA10	homeobox A10	7p15.2
HOXA1	homeobox A1	7p15.2
HOXA11-AS1	HOXA11 antisense RNA 1 (non-protein coding)	7p15.2
UBA52P1	ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 1	7p15.2
SNORD93	small nucleolar RNA, C/D box 93	7p15.3
HOXA11	homeobox A11	7p15.2
HOXA2	homeobox A2	7p15.2
IL6	interleukin 6 (interferon, beta 2)	7p21-p15
RPL23P7	ribosomal protein L23 pseudogene 7	7p15.2
HOXA13	homeobox A13	7p15.2
RPS2P32	ribosomal protein S2 pseudogene 32	7p15.3
FAM126A	family with sequence similarity 126, member A	7p15.3
SKAP2	src kinase associated phosphoprotein 2	7p15.2
PCMTD1P3	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 pseudogene 3	7p15.3
MPP6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	7p15
EVX1	even-skipped homeobox 1	7p15.2
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	7p15
HIBADH	3-hydroxyisobutyrate dehydrogenase	7p15
CDCA7L	cell division cycle associated 7-like	7p15.3
ASS1P11	argininosuccinate synthetase 1 pseudogene 11	7p15.3
MIR1183	microRNA 1183	7
HMGB3P20	high mobility group box 3 pseudogene 20	7p15.2
JAZF1	JAZF zinc finger 1	7p15.2-p15.1
C7orf46	chromosome 7 open reading frame 46	7p15.3
CBX3	chromobox homolog 3	7p15.2
C7orf31	chromosome 7 open reading frame 31	7p15.2

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Region: chr7:20900000..28800000 View in gBrowse